观点：神经类器官的细胞多样性对神经退行性疾病建模至关重要
Cellular diversity in neural organoids is critical for neurodegenerative disease modeling
Shiying Liu与Shi-Yan Ng在PLOS Biology发表观点文章指出，神经炎症和血管功能障碍是多数神经退行性疾病的标志，因此免疫细胞和血管细胞应被视为神经退行性疾病建模类器官的基本组成部分，而非可选添加项。
by Shiying Liu, Shi-Yan Ng
Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune, and vascular cells should therefore be considered fundamental components, rather than optional additions. Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. This Perspective argues that immune and vascular cells need to be fundamental components of organoids intended to model neurodegeneration, rather than optional extras.
来源：PLOS Biology · journals.plos.org