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Nature 干细胞主题·· 3 天前AI 评分38

肺泡干细胞超越气体交换功能：追踪AT2细胞显示其可转分化驱动细支气管再生

Alveolar stem cells go beyond making gas-exchange cells to repair damaged airways

AI 导读

一项追踪肺泡2型（AT2）细胞的研究显示，气道损伤后AT2细胞可在肺不同区域间迁移并转变为细支气管细胞，帮助修复受损气道。该研究由Liu, K.等人完成，论文题为《Alveolar stem cells transdifferentiate to drive bronchiolar regeneration》，发表于Nature（2026）。

正文
  • RESEARCH BRIEFINGS
  • 14 October 2026

Alveolar type 2 (AT2) cells are the stem cells of the lung’s air sacs and are responsible for maintaining alveolar structure and gas exchange. A study that tracked AT2 cells shows that, after injury to the airway, they can also migrate between lung compartments and become bronchiolar cells to help repair damaged airways.

This is a summary of: Liu, K. et al. Alveolar stem cells transdifferentiate to drive bronchiolar regeneration. Nature https://doi.org/10.1038/s41586-026-11127-w (2026).

doi: https://doi.org/10.1038/d41586-026-03085-0

‘Expert opinion’ is published under a CC BY 4.0 licence; Figure 1 is published under a CC BY-NC-ND 4.0 licence.

References

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来源：Nature 干细胞主题 · nature.com

生物科技#论文/研究#干细胞#基础研究#再生医学